Published Work
*Contributed Equally
Systemically targeting monocytic MDSCs using dendrimers and their cell-level biodistribution kinetics
Chad A Littrell, Gregory P Takacs, Chenikkayala Siva Sankara, Alexandra Sherman, Kai A Rubach, Julia S Garcia, Coral Bell, Jeffrey Keith Harrison, Fan Zhang
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy
Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kannan
Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies
Kristin G Anderson, David A Braun, Aitziber Buqué, Sarah B Gitto, Jennifer L Guerriero, Brendan Horton, Bridget P Keenan, Teresa S Kim, Abigail Overacre-Delgoffe, Marco Ruella, Todd A Triplett, Omkara Veeranki, Vivek Verma, Fan Zhang
BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology
S Hao, VV Inamdar, EC Sigmund, F Zhang, SB Stephan, C Watson, SJ Weaver, UB Nielsen, MT Stephan
Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury
O Arteaga Cabeza, Z Zhang, E Smith Khoury, RA Sheldon, A Sharma, F Zhang, BS Slusher, RM Kannan, S Kannan, DM Ferriero
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration.
Liaw K*, Zhang F* Mangraviti A, Kannan S, Tyler B, Kannan RM. Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration. Bioeng Transl Med. 2020;e10160.
Featured on Editor’s Highlight
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.
Liaw K*, Zhang F* Mangraviti A, Kannan S, Tyler B, Kannan RM. Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration. Bioeng Transl Med. 2020;e10160. Zhang F, Parayath N, Coon M, Stephan SB, Ene CI, Holland EC, Stephan MT. Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers. Nature Communications. 10, Article number: 3974 (2019).
Featured Cover Article
Nanoparticles that reshape the tumor milieu create a therapeutic window for effective T cell therapy in solid malignancies.
Zhang F, Stephan SB, Ene CI, Smith TT, Holland EC, Stephan MT. Nanoparticles that reshape the tumor milieu create a therapeutic window for effective T cell therapy in solid malignancies. Cancer Research. 2018. 1;78(13):3718-3730.
Generation-6 hydroxyl PAMAM dendrimers for improved delivery of therapeutics to the brain in a large animal brain injury model.
Zhang F, Magruder T, Lin YA, Crawford TC, Grimm J, Sciortino C, Wilson MA, Blue M, Kannan S, Johnston M, Baumgartner W, Kannan RM. Generation-6 hydroxyl PAMAM dendrimers for improved delivery of therapeutics to the brain in a large animal brain injury model. J Control Release. 2017. 249:173-182.
Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury.
Grimm JC*, Zhang F*, Beaty CA, Mishra M, Magruder JT, Kannan RM, Shah A. Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury. J Surg Res. 2017. 210:78-85.ff
Surface functionality affects the biodistribution and targeting to neuroinflammation for intra-amniotically delivered dendrimers.
Zhang F, Nance E, Jasty V, Mishra MK, Kambhampati SP, Zhang Z, Kannan RM, Kannan S. Surface functionality affects the biodistribution and targeting to neuroinflammation for intra-amniotically delivered dendrimers. J Control Release. 2016. 10;237:61-70.
Review article
Targeting Specific Cells in the Brain with Nanomedicines for CNS Therapies.
Zhang F, Lin YA, Kannan S, Kannan RM. Targeting Specific Cells in the Brain with Nanomedicines for CNS Therapies. J Control Release. 2016. 240:212-226.
Microglia migration and interactions with dendrimer in brain in the presence of neuroinflammation.
Zhang F, Nance E, Alnasser Y, Kannan RM, Kannan S. Microglia migration and interactions with dendrimer in brain in the presence of neuroinflammation. J Neuroinflammation. 2016 Mar 22;13(1):65.
PAMAM Dendrimer Biodistribution in Glioblastoma and Intrinsic Targeting of Tumor Associated Macrophages.
Zhang F*, Mastorakos P*, Mishra M, Mangraviti A, Hwang L, Zhou J, Hanes J, Brem H, Olivi A, Tyler B, Kannan RM. PAMAM Dendrimer Biodistribution in Glioblastoma and Intrinsic Targeting of Tumor Associated Macrophages. Biomaterials. 2015. 52:507-16.
Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth.
Burd I*, Zhang F*, Dada T, Mishra MK, Borbiev T, Lesniak WG, Baghlaf H, Kannan S, Kannan RM. Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth. Nanomedicine. 2014. 10(6):1343-51.
Co-Author Publications
2020
- O Arteaga Cabeza, Z Zhang, E Smith Khoury, RA Sheldon, A Sharma, F Zhang, BS Slusher, RM Kannan, S Kannan, DM Ferriero. Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury. Neurobiol Dis . 2020 Nov 30;148:105201. doi: 10.1016/j.nbd.2020.105201
2018
- Niño DF, Zhou Q, Yamaguchi Y, Martin LY, Wang S, Fulton WB, Jia H, Lu P, Prindle T Jr, Zhang F, Crawford J, Hou Z, Mori S, Chen LL, Guajardo A, Fatemi A, Pletnikov M, Kannan RM, Kannan S, Sodhi CP and Hackam DJ. Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain. Sci Transl Med. 2018 Dec 12;10(471).
- Nance E, Kambhampati SP, Smith ES, Zhang Z, Zhang F, Singh S, Johnston MV, Kannan RM, Blue ME7, Kannan S. Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome. J Neuroinflammation. 2018. 14(1):252.
2017
- Nemeth CL, Drummond GT, Mishra MK, Zhang F, Carr P, Kannan RM, Fatemi A, Johnston MV, Kannan S, Wilson MA. Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia. Nanomedicine. 2017. 13(7):2359-2369
- Magruder JT, Crawford TC, Lin YA, Zhang F, Grimm JC, Kannan RM, Kannan S, Sciortino CM. Selective Localization of a Novel Dendrimer Nanoparticle in Myocardial Ischemia-Reperfusion Injury. Ann Thorac Surg. 2017. pii: S0003-4975(17)30052-8.
- Nance E, Zhang F, Mishra M, Zhang Z, Kambhampati SP, Kannan RM, Kannan S. Nanoscale effects in dendrimer-mediated targeting of neuroinflammation. Biomaterials. 2016. 101:96-107.
2013-16
- Grimm JC, Magruder T, Wilson MA, Blue ME, Crawford TC, Troncoso JC, Zhang F, Kannan S, Sciortino CM, Johnston MV, Kannan RM, Baumgartner WA. Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury. Ann Thorac Surg. 2016. pii: S0003-4975(16)00262-9.
- Nance E, Porambo M, Zhang F, Mishra MK, Buelow M, Getzenberg R, Johnston M, Kannan RM, Fatemi A, Kannan S. Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury. J Control Release. 2015. 214:112-20.
- Mishra MK, Beaty CA, Lesniak WG, Kambhampati SP, Zhang F, Wilson MA, Blue ME, Troncoso JC, Kannan S, Johnston MV, Baumgartner WA, Kannan RM. Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest. ACS Nano. 2014. 8:2134-47.
- Lesniak WG, Mishra MK, Jyoti A, Balakrishnan B, Zhang F, Nance E, Romero R, Kannan S, Kannan RM. Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: effect of neuroinflammation. Mol Pharm. 2013. 10:4560-71.
- SK UH, Kambhampati SP, Mishra MK, Lesniak WG, Zhang F, Kannan RM. Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study. Biomacromolecules. 2013. 14:801-10.